SymptomsMany people with unicentric Castleman disease don't notice any signs or symptoms. The enlarged lymph node may be detected during a physical exam or an imaging test for some unrelated problem.
Some people with unicentric Castleman disease might experience signs and symptoms more common to multicentric Castleman disease, which may include:
• Unintended weight loss
• Night sweats
• Enlarged liver or spleen
The enlarged lymph nodes associated with multicentric Castleman disease are most commonly located in the neck, collarbone, underarm and groin areas.
CausesIt's not clear what causes Castleman disease. However, infection by a virus called human herpesvirus 8 (HHV-8) is associated with multicentric Castleman disease.
The HHV-8 virus has also been linked to the development of Kaposi's sarcoma, a cancerous tumor that can be a complication of HIV/AIDS. Studies have found that HHV-8 is present in nearly all HIV-positive people who have Castleman disease, and in about half of HIV-negative people with Castleman disease.
More about Treatment
Castleman disease is a rare disorder that involves an overgrowth of cells in your body's lymph nodes. The most common form of the disorder affects a single lymph node (unicentric Castleman disease), usually in the chest or abdomen. Multicentric Castleman disease affects multiple lymph nodes throughout the body and has been associated with human herpes virus type 8 (HHV-8) and human immunodeficiency virus (HIV). Treatment and outlook vary, depending on the variety of Castleman disease you have. The type that affects only one lymph node can usually be successfully treated with surgery.
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