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Lynch Syndrome

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Lynch Syndrome

Lynch Syndrome

According to a study, Lynch syndrome is the most common inherited cancer syndrome, affecting as many as 1 in every 370 people in Western countries. Lynch syndrome causes about 4,000 colorectal cancers and 1,800 uterine cancers per year. This condition is a type of inherited cancer syndrome associated with a genetic predisposition to different cancer types. Lynch syndrome is diagnosed by DNA analysis and genetic testing.

What is Lynch Syndrome?

Lynch syndrome, also known as "hereditary non-polyposis colorectal cancer", is a type of inherited cancer syndrome associated with a genetic predisposition to different cancer types.

Lynch syndrome is an inherited condition that increases a person’s risk of developing colorectal cancer and other forms of cancer.

Symptoms

The signs and symptoms of this condition may include:

  • Weight loss
  • Stomach pain
  • Fatigue
  • Constipation

Causes

Lynch syndrome is a genetic disorder and it occurs when a person inherits a mutated gene. Lynch syndrome happens as a result of inherited changes in genes that affect DNA mismatch repair. 

Lynch syndrome is caused by a harmful change (mutation) in one of five genes: MLH1, MSH2, MSH6, PMS2, or EPCAM. The most common mutations occur in MLH1 and MSH2. Lynch syndrome runs in families in an autosomal dominant inheritance pattern. This implies that if one parent carries a gene mutation for Lynch syndrome, there's a 50 percent chance that mutation will be passed on to each child. However, not everyone with Lynch syndrome will get cancer.



More about Treatment

Risk Factors

Certain people are prone to be affected by the condition considering the following factors:

  • Colorectal or endometrial cancer diagnosis before the age of 50.
  • Diagnosis of colorectal or any other cancer associated with Lynch syndrome.
  • A family history of colon cancer that occurs at a young age
  • A family history of  other related cancers, including ovarian cancer, kidney cancer, stomach cancer, small intestine cancer, liver cancer, sweat gland cancer, and other cancers

Complications 

The main complication of Lynch syndrome is colorectal cancer. However individuals can also develop noncancerous colon polyps and if ignored, colon polyps can cause the following symptoms:

  • Anemia
  • Stomach pain
  • Constipation or diarrhea
  • Fatigue

Diagnosis

Lynch syndrome is diagnosed by DNA analysis and genetic testing and this is done after a review of the individual's personal and family medical history to determine their likelihood of having lynch syndrome. 

Treatments

The type of treatment for Lynch syndrome varies and it depends on whether a person shows signs of colorectal cancer. The specific treatment will depend on the stage of diagnosis and the patient’s overall health.

  • Regular colonoscopies and cancer screenings are carried out on people who have Lynch syndrome but have not developed cancer. Prophylactic colectomy (removal of the colon before colon cancer develops) is also an option.

The following treatments are available for people who have Lynch syndrome and have developed colorectal cancer.

  • Polypectomy:

Polypectomy is a surgical procedure that involves the removal of cancerous polyps lining the colon.

  • Colectomy:

Colectomy is a surgical procedure that involves removing all or part of the colon as well as any affected lymph nodes.

  • Ablation:

Ablation is a procedure that involves the use of radiofrequency waves, including microwaves, to destroy small tumors.

  • Cryosurgery:

Cryosurgery is a procedure that involves the use of a  thin metal probe to administer cold gas to the surface of a tumor to kill the cancer cells.

  • Embolization:

Embolization is a technique that involves the use of a thin tube inserted into an artery  to block the flow of blood to a large tumor

FAQ

  • What causes Lynch Syndrome?

Lynch syndrome is caused by a harmful change (mutation) in one of five genes: MLH1, MSH2, MSH6, PMS2, or EPCAM. The most common mutations occur in MLH1 and MSH2.

  • Is Lynch Syndrome hereditary?

Yes, Lynch syndrome is an inherited condition that increases a person’s risk of developing colorectal cancer and other forms of cancer.

  • Does having Lynch syndrome mean I will have cancer?

No, not everyone with Lynch syndrome will get cancer.

  •  What are the Signs of Lynch Syndrome?

Having colon cancer before that age of 50 is a possible sign of Lynch syndrome. Also, another sign that may suggest a risk of Lynch syndrome is if people in your family had colon cancer when they were young.

  • What are the treatment options for Lynch syndrome

Treatment for Lynch syndrome varies depending on whether the patient has colon cancer. Lynch syndrome can be treated via:

  1. Surgery
  2. Chemotherapy and
  3. Immunotherapy




Top Doctors For Lynch Syndrome Treatment

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Dr. K. Satish Srinivas Cancer | Gender: Male | Experience: 15 years | Hospital: Sri Ramachandra Medical Centre (SRMC)
Dr. Asmita Jain Cancer | Gender: Female | Experience: 13 years | Hospital: Primus Super Speciality Hospital, Delhi
Dr. Abhay Kumar Cancer | Gender: Male | Experience: 10 years | Hospital: Narayana Hospital
Dr. Amit Rauthan Cancer | Gender: Male | Experience: 17 years | Hospital: Manipal Hospitals, Bengaluru
Dr. Archana Shetty Cancer | Gender: Female | Experience: 21 years | Hospital: Kokilaben Dhirubhai Ambani Hospital
Dr. Feroz Pasha Cancer | Gender: Male | Experience: 18 years | Hospital: Apollo Indraprastha
Dr. G. K. Jadhav Cancer | Gender: Male | Experience: 25 years | Hospital: Apollo Indraprastha
Dr. Rohit Nayyar Cancer | Gender: Male | Experience: 10 years | Hospital: Max Super Speciality Hospital, Saket
Dr. Sharan Choudhri Cancer | Gender: Male | Experience: 25 years | Hospital: Max Super Speciality Hospital, Saket
Dr. Nidha Iqbal Shapoo Cancer | Gender: Female | Experience: 5 years | Hospital: Thumbay Hospital, Dubai
Dr. Rajeev Kaushal Cancer | Gender: Male | Experience: 27 years | Hospital: Saudi German Hospital
Dr. Balaji Balasubramaniam Cancer | Gender: Male | Experience: 15 years | Hospital: NMC Royal AbuDhabi
Dr. Sai Babu Jonnada Cancer | Gender: Male | Experience: 16 years | Hospital: NMC Royal AbuDhabi
Dr. Mohanad Diab Cancer | Gender: Male | Experience: 15 years | Hospital: NMC Royal AbuDhabi
Dr. Sadir Alrawi Cancer | Gender: Male | Experience: 28 years | Hospital: NMC Royal AbuDhabi
Dr. Moujahed (Ed) Ashtar Cancer | Gender: Male | Experience: 29 years | Hospital: NMC Royal AbuDhabi
Dr. Khaled Kouteich Cancer | Gender: Male | Experience: 28 years | Hospital: Al Zahra Dubai
Dr. Sujay Susikar Cancer | Gender: Male | Experience: 10 years | Hospital: Fortis Malar Hospital, Chennai
Dr. Bellarmine Cancer | Gender: Male | Experience: 37 years | Hospital: Fortis Malar Hospital, Chennai
Dr. S Annalakshmi Cancer | Gender: Female | Experience: 10 years | Hospital: HCG Cancer Centre
Dr. Radheshyam Naik Cancer | Gender: Male | Experience: 25 years | Hospital: HCG Cancer Centre
Dr. Premita Cancer | Gender: Female | Experience: 10 years | Hospital: HCG Cancer Centre
Dr. Prabhu Nesargikar Cancer | Gender: Male | Experience: 10 years | Hospital: HCG Cancer Centre
Dr. Mahesh Bandemegal Cancer | Gender: Male | Experience: 10 years | Hospital: HCG Cancer Centre
Dr. Lohith Reddy Cancer | Gender: Male | Experience: 10 years | Hospital: HCG Cancer Centre
Dr. Krithika Murugan Cancer | Gender: Female | Experience: 10 years | Hospital: HCG Cancer Centre
Dr. Jagannath Dixit Cancer | Gender: Male | Experience: 16 years | Hospital: HCG Cancer Centre
Dr. Belliappa Cancer | Gender: Male | Experience: 10 years | Hospital: HCG Cancer Centre
Dr. Akshay Kudpaje Cancer | Gender: Male | Experience: 10 years | Hospital: HCG Cancer Centre
Dr. Shabeena Rana Cancer | Gender: Female | Experience: 17 years | Hospital: Al Zahra Dubai
Dr. Anil Kumar Cancer | Gender: Male | Experience: 9 years | Hospital: Fortis Hospital, Bengaluru
Dr. Reetesh Ranjan Cancer | Gender: Male | Experience: 10 years | Hospital: BLK Hospitals
Dr. S. Jayalakshmi Cancer | Gender: Female | Experience: 10 years | Hospital: Artemis Hospital, Delhi
Dr. Priya Tiwari Cancer | Gender: Female | Experience: 10 years | Hospital: Artemis Hospital, Delhi
Prof. Hale Başak Çağlar Cancer | Gender: Female | Experience: 10 years | Hospital: Anadolu Hospital
Prof. Dr. Bülent Karagöz Cancer | Gender: Male | Experience: 10 years | Hospital: Anadolu Hospital
Prof. N. Yalçın İlker Cancer | Gender: Male | Experience: 10 years | Hospital: Anadolu Hospital
Dr. Mehmet Doğu Canoğlu Cancer | Gender: Male | Experience: 10 years | Hospital: Anadolu Hospital
Dr. Harsh Dua Cancer | Gender: Male | Experience: 25 years | Hospital: Apollo Indraprastha
Dr. Manish Singhal Cancer | Gender: Male | Experience: 16 years | Hospital: Apollo Indraprastha
Dr. Abuchi Okaro Cancer | Gender: Male | Experience: 20 years | Hospital: Euracare Multi-Specialist Hospital
Dr. Syed Azim Razvi Cancer | Gender: Male | Experience: 10 years | Hospital: Apollo Indraprastha
Dr. S. Hukku Cancer | Gender: Male | Experience: 25 years | Hospital: BLK Hospitals
Dr. Surender Kumar Dabas Cancer | Gender: Male | Experience: 7 years | Hospital: BLK Hospitals
Dr. Amit Agarwal Cancer | Gender: Male | Experience: 10 years | Hospital: BLK Hospitals

Top Hospitals For Lynch Syndrome Treatment

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    238

Cytecare Hospitals At Cytecare, they understand and stress on the right way of fighting cancer. This gives rise to a mu
Columbia Asia Hospital, Bengaluru Columbia Asia is an international healthcare group operating a chain of modern hospitals across Indi
Gleaneagles Global Hospital, Mumbai Gleneagles Global Hospital, Mumbai offers end-to-end clinical, surgical and diagnostic services. The
Kerala Institute of Medical Sciences (KIMS), Trivandrum KIMS HEALTHCARE GROUP is one of Asia’s leading multi-specialty hospital networks focussed on provi
Max Super Speciality Hospital, Saket Max Smart Super Speciality Hospital, Saket (a unit of Gujarmal Modi Hospital & Research Centre for M
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