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Nephroblastoma (Wilms Tumor)

Nephroblastoma (Wilms Tumor)

Nephroblastoma, which is also known as Wilms’ tumor is a type of rare kidney cancer that often occurs in children. This type of kidney cancer is also the fourth very most common type of childhood cancer and roughly around 500 children in the world are newly diagnosed with the situation each year. Mostly, Wilms’ tumor is typically diagnosed in kids around 3 years of age. This rare kidney cancer can sometimes occur in older children and adults too.

Symptoms

What are the common signs and symptoms of Wilms’ tumor?

Children in the age group of 2 to 4 who are diagnosed with Wilms’ tumor often show these following signs and symptoms.

  • Constipation
  • Swelling, discomfort and pain in the abdomen
  • Nausea and vomiting
  • Weakness and fatigue
  • Loss of appetite
  • Fever
  • Discoloration or blood in the urine
  • High blood pressure
  • Shortness of breath

Causes

What causes Wilms’ tumor?

Though researchers still haven’t found what actually causes Nephroblastoma or any clear links between the disease and environmental factors, these are few factors that cause the Wilms’ tumor

Genetic Factors:

Though children don’t directly inherit the condition from their parents, researchers believe certain factors might raise the chance of a child developing Wilms’ tumor genetically. These are the following genetic syndromes that increase the chances of a child being diagnosed with Nephroblastoma:

  • WAGR syndrome
  • Densys-Drash syndrome
  • Bloom syndrome
  • Perlman syndrome
  • Sotos syndrome
  • Edward’s syndrome (Also called Trisomy 18)
  • Frasier syndrome
  • Beckwith - Wiedemann syndrome

Frasier, WAGR and Denys-Drash syndrome are linked to mutations in the WT1 gene. Beckwith-Wiedemann syndrome, on the other hand, is linked to mutations in the WT2 gene, All these both genes are found in chromosome 11. And changes in these genes account for a small percentage of Nephroblastoma in children below 3 years of age. Apart from that, children with certain birth defects are also more likely to develop Nephroblastoma. These are the following birth defects that are associated with the condition.

  • Aniridia
  • Hemihypertrophy
  • Cryptorchidism
  • Hypospadias

More about Treatment

Wilms’ tumors are generally classified into different types under a microscope by looking at the tumor cells and this process is called “Histology”.

  • Unfavorable Histology:
  • This type of tumor has a nucleus in the cells and often looks very large and distorted in unfavorable histology. This type of tumor is often referred to as Anaplasia. The harder the tumor is to cure when there is more Anaplasia.

  • Favorable Histology:
  • This type of tumor doesn’t have Anaplasia. Most tumors are easier to cure since over 90 percent of Wilms’ tumors have favorable histology.

    Treatment procedure of Wilms’ Tumor:

    Few of the main type of treatment procedures involved in treating Wilms’ tumor are as follows:

  • Surgery
  • Radiation Therapy
  • Chemotherapy
  • Most of the time, children undergo a combination of treatments. Surgery is generally the first treatment that doctors advise the patient with the main goal of the surgery is to remove the tumor. Just in case, the surgery isn’t successful, the child has to undergo chemotherapy or radiation therapy if the tumor wasn’t removed successfully. Apart from that, medications and the extent of treatment will normally vary depending on the child's condition.

    FAQ

    • What is the life expectancy of a child with Nephroblastoma?

    The five-year survival rate of a kid with Nephroblastoma is 81%. 

    • What are the side effects and complications involved in Wilms’ tumor?

    Unlike any cancer, the spreading of the disease to almost all organs is a serious complication. And some of the side effects due to the treatment are as follows: Hair loss, fatigue, nausea and vomiting.

    • Can Nephroblastoma be prevented?

    While this type of cancer can’t be prevented, the various screening tools can always ensure early detection.

    • Where does Wilms’ tumor metastasis occur?

    Nephroblastoma can mostly spread to lymph nodes in the abdomen as well as to the lung (rarely to the liver). It does not spread to the bones, bone marrow, or brain.

    • Can Wilms’ tumor relapse?

    Most of the time relapses occur within two years of diagnosis of the original Wilms' tumour occurrence, yet for some children it can come back later than this. And this is for 85% of cases.

    Top Doctors For Nephroblastoma (Wilms Tumor) Treatment

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    Dr. K. Satish Srinivas Cancer | Gender: Male | Experience: 15 years | Hospital: Sri Ramachandra Medical Centre (SRMC)
    Dr. Asmita Jain Cancer | Gender: Female | Experience: 13 years | Hospital: Primus Super Speciality Hospital, Delhi
    Dr. Abhay Kumar Cancer | Gender: Male | Experience: 10 years | Hospital: Narayana Hospital
    Dr. Amit Rauthan Cancer | Gender: Male | Experience: 17 years | Hospital: Manipal Hospitals, Bengaluru
    Dr. Archana Shetty Cancer | Gender: Female | Experience: 21 years | Hospital: Kokilaben Dhirubhai Ambani Hospital
    Dr. Feroz Pasha Cancer | Gender: Male | Experience: 18 years | Hospital: Apollo Indraprastha
    Dr. G. K. Jadhav Cancer | Gender: Male | Experience: 25 years | Hospital: Apollo Indraprastha
    Dr. Rohit Nayyar Cancer | Gender: Male | Experience: 10 years | Hospital: Max Super Speciality Hospital, Saket
    Dr. Sharan Choudhri Cancer | Gender: Male | Experience: 25 years | Hospital: Max Super Speciality Hospital, Saket
    Dr. Nidha Iqbal Shapoo Cancer | Gender: Female | Experience: 5 years | Hospital: Thumbay Hospital, Dubai
    Dr. Rajeev Kaushal Cancer | Gender: Male | Experience: 27 years | Hospital: Saudi German Hospital
    Dr. Balaji Balasubramaniam Cancer | Gender: Male | Experience: 15 years | Hospital: NMC Royal AbuDhabi
    Dr. Sai Babu Jonnada Cancer | Gender: Male | Experience: 16 years | Hospital: NMC Royal AbuDhabi
    Dr. Mohanad Diab Cancer | Gender: Male | Experience: 15 years | Hospital: NMC Royal AbuDhabi
    Dr. Sadir Alrawi Cancer | Gender: Male | Experience: 28 years | Hospital: NMC Royal AbuDhabi
    Dr. Moujahed (Ed) Ashtar Cancer | Gender: Male | Experience: 29 years | Hospital: NMC Royal AbuDhabi
    Dr. Khaled Kouteich Cancer | Gender: Male | Experience: 28 years | Hospital: Al Zahra Dubai
    Dr. Sujay Susikar Cancer | Gender: Male | Experience: 10 years | Hospital: Fortis Malar Hospital, Chennai
    Dr. Bellarmine Cancer | Gender: Male | Experience: 37 years | Hospital: Fortis Malar Hospital, Chennai
    Dr. S Annalakshmi Cancer | Gender: Female | Experience: 10 years | Hospital: HCG Cancer Centre
    Dr. Radheshyam Naik Cancer | Gender: Male | Experience: 25 years | Hospital: HCG Cancer Centre
    Dr. Premita Cancer | Gender: Female | Experience: 10 years | Hospital: HCG Cancer Centre
    Dr. Prabhu Nesargikar Cancer | Gender: Male | Experience: 10 years | Hospital: HCG Cancer Centre
    Dr. Mahesh Bandemegal Cancer | Gender: Male | Experience: 10 years | Hospital: HCG Cancer Centre
    Dr. Lohith Reddy Cancer | Gender: Male | Experience: 10 years | Hospital: HCG Cancer Centre
    Dr. Krithika Murugan Cancer | Gender: Female | Experience: 10 years | Hospital: HCG Cancer Centre
    Dr. Jagannath Dixit Cancer | Gender: Male | Experience: 16 years | Hospital: HCG Cancer Centre
    Dr. Belliappa Cancer | Gender: Male | Experience: 10 years | Hospital: HCG Cancer Centre
    Dr. Akshay Kudpaje Cancer | Gender: Male | Experience: 10 years | Hospital: HCG Cancer Centre
    Dr. Shabeena Rana Cancer | Gender: Female | Experience: 17 years | Hospital: Al Zahra Dubai
    Dr. Anil Kumar Cancer | Gender: Male | Experience: 9 years | Hospital: Fortis Hospital, Bengaluru
    Dr. Reetesh Ranjan Cancer | Gender: Male | Experience: 10 years | Hospital: BLK Hospitals
    Dr. S. Jayalakshmi Cancer | Gender: Female | Experience: 10 years | Hospital: Artemis Hospital, Delhi
    Dr. Priya Tiwari Cancer | Gender: Female | Experience: 10 years | Hospital: Artemis Hospital, Delhi
    Prof. Hale Başak Çağlar Cancer | Gender: Female | Experience: 10 years | Hospital: Anadolu Hospital
    Prof. Dr. Bülent Karagöz Cancer | Gender: Male | Experience: 10 years | Hospital: Anadolu Hospital
    Prof. N. Yalçın İlker Cancer | Gender: Male | Experience: 10 years | Hospital: Anadolu Hospital
    Dr. Mehmet Doğu Canoğlu Cancer | Gender: Male | Experience: 10 years | Hospital: Anadolu Hospital
    Dr. Harsh Dua Cancer | Gender: Male | Experience: 25 years | Hospital: Apollo Indraprastha
    Dr. Manish Singhal Cancer | Gender: Male | Experience: 16 years | Hospital: Apollo Indraprastha
    Dr. Abuchi Okaro Cancer | Gender: Male | Experience: 20 years | Hospital: Euracare Multi-Specialist Hospital
    Dr. Syed Azim Razvi Cancer | Gender: Male | Experience: 10 years | Hospital: Apollo Indraprastha
    Dr. S. Hukku Cancer | Gender: Male | Experience: 25 years | Hospital: BLK Hospitals
    Dr. Surender Kumar Dabas Cancer | Gender: Male | Experience: 7 years | Hospital: BLK Hospitals
    Dr. Amit Agarwal Cancer | Gender: Male | Experience: 10 years | Hospital: BLK Hospitals

    Top Hospitals For Nephroblastoma (Wilms Tumor) Treatment

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    Cytecare Hospitals At Cytecare, they understand and stress on the right way of fighting cancer. This gives rise to a mu
    Columbia Asia Hospital, Bengaluru Columbia Asia is an international healthcare group operating a chain of modern hospitals across Indi
    Gleaneagles Global Hospital, Mumbai Gleneagles Global Hospital, Mumbai offers end-to-end clinical, surgical and diagnostic services. The
    Kerala Institute of Medical Sciences (KIMS), Trivandrum KIMS HEALTHCARE GROUP is one of Asia’s leading multi-specialty hospital networks focussed on provi
    Max Super Speciality Hospital, Saket Max Smart Super Speciality Hospital, Saket (a unit of Gujarmal Modi Hospital & Research Centre for M
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