Paget's disease of bone interferes with your body's normal recycling process, in which new bone tissue gradually replaces old bone tissue. Over time, the disease can cause affected bones to become ...
Most people who have Paget's disease of bone have no symptoms. When symptoms occur, the most common complaint is bone pain.
Because this disease causes your body to generate new bone faster than normal, the rapid remodeling produces bone that's softer and weaker than normal bone, which can lead to bone pain, deformities and fractures.
The disease might affect only one or two areas of your body or might be widespread. Your signs and symptoms, if any, will depend on the affected part of your body.
• Pelvis: Paget's disease of bone in the pelvis can cause hip pain.
• Skull: An overgrowth of bone in the skull can cause hearing loss or headaches.
• Spine: If your spine is affected, nerve roots can become compressed. This can cause pain, tingling and numbness in an arm or leg.
• Leg: As the bones weaken, they may bend causing you to become bowlegged. Enlarged and misshapen bones in your legs can put extra stress on nearby joints, which may cause osteoarthritis in your knee or hip.
The cause of Paget's disease of bone is unknown. Scientists suspect a combination of environmental and genetic factors contribute to the disease. Several genes appear to be linked to getting the disease.
Some scientists believe Paget's disease of bone is related to a viral infection in your bone cells, but this theory is controversial.
More about Treatment
Paget's disease of bone interferes with your body's normal recycling process, in which new bone tissue gradually replaces old bone tissue. Over time, the disease can cause affected bones to become fragile and misshapen. Paget's disease of bone most commonly occurs in the pelvis, skull, spine and legs.
The risk of Paget's disease of bone increases with age. Your risk also increases if any family members have the disorder. Complications of Paget's disease of bone can include broken bones, hearing loss and pinched nerves in your spine.
Bisphosphonates the medications also used to strengthen bones weakened by osteoporosis are the mainstay of treatment. For patients who have complications, surgery may be necessary.
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